Ozlem Goker-Alpan Selected Research

Glucosylceramidase (Glucocerebrosidase)

1/2022	Lysosomal functions and dysfunctions: Molecular and cellular mechanisms underlying Gaucher disease and its association with Parkinson disease.
1/2021	Cellular and biochemical response to chaperone versus substrate reduction therapies in neuropathic Gaucher disease.
1/2020	Effect of Substrate Reduction Therapy in Comparison to Enzyme Replacement Therapy on Immune Aspects and Bone Involvement in Gaucher Disease.
1/2018	Enzyme replacement therapy reverses B lymphocyte and dendritic cell dysregulations in patients with Gaucher Disease.
1/2018	Individualized screening for chaperone activity in Gaucher disease using multiple patient derived primary cell lines.
1/2018	Gaucheromas: When macrophages promote tumor formation and dissemination.
11/2016	New Directions in Gaucher Disease.
8/2012	The neurobiology of glucocerebrosidase-associated parkinsonism: a positron emission tomography study of dopamine synthesis and regional cerebral blood flow.
12/2011	Bilateral symmetrical cortical osteolytic lesions in two patients with Gaucher disease.
12/2011	Skin ultrastructural findings in type 2 Gaucher disease: diagnostic implications.

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Ozlem Goker-Alpan Research Topics

Disease

32	Gaucher Disease (Gaucher's Disease) 01/2022 - 01/2004
12	Fabry Disease (Fabry's Disease) 09/2020 - 01/2015
8	Parkinsonian Disorders (Parkinsonism) 08/2012 - 01/2004
7	Glycogen Storage Disease Type II (Pompe's Disease) 05/2022 - 01/2015
7	Parkinson Disease (Parkinson's Disease) 04/2016 - 01/2004
3	Synucleinopathies 01/2022 - 01/2006
3	Thrombocytopenia (Thrombopenia) 12/2016 - 04/2014
2	Disease Progression 01/2022 - 04/2016
2	Inflammation (Inflammations) 09/2020 - 01/2015
2	Fever (Fevers) 09/2020 - 04/2014
2	Pain (Aches) 09/2020 - 01/2019
2	Inborn Genetic Diseases (Disease, Hereditary) 01/2019 - 08/2007
2	Anemia 12/2016 - 04/2014
2	Bone Diseases (Bone Disease) 01/2016 - 12/2011
2	Lewy Body Disease (Lewy Body Dementia) 11/2010 - 01/2006
1	Myocardial Infarction 12/2021
1	Angioedema 09/2020
1	Diarrhea 09/2020
1	Vomiting 09/2020
1	Neoplasms (Cancer) 01/2018
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2017
1	Phenylketonurias (Phenylketonuria) 01/2017
1	Dementia (Dementias) 04/2016
1	Hypersplenism (Anemia, Splenic) 01/2016
1	Transient Ischemic Attack 01/2015
1	Heart Failure 01/2015
1	Eosinophilic Esophagitis 01/2015
1	Missed Abortion 04/2014
1	Birth Weight (Birth Weights) 04/2014
1	Hemorrhage 04/2014
1	Myoclonic Epilepsies (Myoclonic Encephalopathy) 11/2011
1	Pathologic Processes 07/2010
1	Hypercholesterolemia 05/2002

Drug/Important Bio-Agent (IBA)

22	Glucosylceramidase (Glucocerebrosidase)IBA 01/2022 - 01/2004
20	EnzymesIBA 01/2022 - 01/2004
10	AcidsIBA 05/2022 - 01/2016
7	GlucosidasesIBA 05/2022 - 01/2016
7	GalactosidasesIBA 09/2020 - 01/2015
7	agalsidase alfaIBA 01/2020 - 01/2015
5	Glucosylceramides (Glucocerebrosides)IBA 01/2021 - 12/2011
4	GlycogenIBA 05/2022 - 01/2016
4	Biomarkers (Surrogate Marker)IBA 01/2022 - 05/2002
4	human GAA protein (Myozyme)FDA Link 12/2021 - 01/2015
4	agalsidase beta FDA Link 01/2019 - 01/2015
3	imiglucerase FDA Link 01/2017 - 05/2014
3	migalastatIBA 01/2017 - 01/2015
3	eliglustatIBA 01/2017 - 02/2016
3	Proteins (Proteins, Gene)FDA Link 07/2010 - 12/2008
2	Ambroxol (Mucosolvan)IBA 01/2018 - 02/2013
2	GlycosphingolipidsIBA 01/2017 - 01/2016
2	globotriaosylceramide (globotriosylceramide)IBA 01/2017 - 01/2015
2	Levodopa (L Dopa)FDA LinkGeneric 04/2016 - 01/2006
2	Pharmaceutical PreparationsIBA 01/2016 - 01/2015
1	SynucleinsIBA 01/2022
1	Immunoglobulin E (IgE)IBA 09/2020
1	alpha-Glucosidases (Acid Maltase)IBA 09/2020
1	Vitamin D FDA LinkGeneric 01/2019
1	LipidsIBA 01/2019
1	CalciumIBA 01/2019
1	A-factor (Streptomyces)IBA 01/2018
1	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 01/2018
1	Nitric Oxide Synthase (NO Synthase)IBA 01/2017
1	Hemoglobins (Hemoglobin)IBA 01/2017
1	sapropterin (tetrahydrobiopterin)FDA Link 01/2017
1	AntioxidantsIBA 01/2017
1	Indicators and Reagents (Reagents)IBA 04/2016
1	ceramide glucosyltransferaseIBA 02/2016
1	sphingosyl beta-glucosideIBA 02/2016
1	Omalizumab (Xolair)FDA Link 01/2015
1	anti-IgE antibodiesIBA 01/2015
1	Dopamine (Intropin)FDA LinkGeneric 08/2012
1	CeramidesIBA 12/2011
1	Complementary DNA (cDNA)IBA 11/2011
1	Lysosomal Membrane ProteinsIBA 11/2011
1	Phosphotransferases (Kinase)IBA 08/2006
1	Leucine (L-Leucine)FDA Link 08/2006

Therapy/Procedure

19	Enzyme Replacement Therapy 05/2022 - 12/2011
11	Therapeutics 12/2021 - 08/2007
1	Enzyme Therapy 01/2017
1	Splenectomy 01/2016
1	Arthroplasty 04/2014
1	Cesarean Section (Caesarean Section) 04/2014
1	Duration of Therapy 12/2011